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Poor/Substantial Metabolizers, CYP2D6 The development from the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately 7% of the populace has decreased action in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme program. These persons are “inadequate metabolizers” of debrisoquine, dextromethorphan and tric